For example, activation of NLRP3 inflammasomes was observed in kidney biopsies from patients with type IV LN as well as in the SLE–prone MRL/lpr mice and NZM2328 mice [27, 28], presenting the NLRP3 inflammasome as a therapeutic target in LN and SLE. The gene discussed is NLRP3; the disease is systemic lupus erythematosus.