The results of Masson staining showed the reduction of collagen deposition in Zbp1 siRNA-GeRP-treated injured livers (Fig. 9G), which was in accordance with the decreases of Acta2 (α-SMA, the marker of liver fibrosis), Col1a1 (Col I) and Col3a1 expressions in Zbp1 siRNA-GeRPs-injection groups (Fig. 9E, F). Here, ZBP1 is linked to Hepatic fibrosis.