A combination of keywords related to alpha-synuclein, synaptic plasticity and Parkinson’s disease was used: “alpha-synuclein”, “neuroinflammation”, “neurodegeneration”, “Lewy bodies”, “Parkinson’s disease”, “striatal dopaminergic transmission”, “synucleinopathies”, “synaptopathy”, “synaptic plasticity”, “presynaptic”, “postsynaptic, “toxicity”, “misfolded”, “aggregation”, “oligomers”, “fibrils”, “animal models”, “mechanisms”, “Lewy body dementia”, “multiple system atrophy”, “pure autonomic failure”, “REM behavior disorder”. The gene discussed is SNCA; the disease is Parkinson disease.