Together, the findings described here suggest that maternal genetics may influence the risk of the occurrence of CZS and that the genetics of children affected with CZS are associated with the severity of the syndrome, suggesting that an impaired antiviral response is associated with the immunopathogenesis of congenital ZIKV infection, and placing the genes TREM1, IL4, CXCL10, CXCL8 and TLR7 as promising genes for future functional studies, for a better understanding of their respective roles in the occurrence of CZS. Here, IL4 is linked to Zika virus infectious disease.