Therefore, the data presented here suggest that this genetic variation in the TREM1 gene in pregnant women may influence the risk of developing CZS in their infants, indicating that lower expression/activation of TREM-1 may affect the control of ZIKV infection, which reinforces the need for a better understanding of the role of TREM-1 in the pathogenesis of CZS. The gene discussed is TREM1; the disease is Zika virus infectious disease.