In this study, TREM1 rs2234246 and IL4 rs224325 in mothers infected with ZIKV during pregnancy was found to be associated with the occurrence of CZS microcephaly and the SNP CXCL10 rs4508917 and CXCL8 rs4073 in their children with presence of CZS microcephaly. The gene discussed is CXCL8; the disease is microcephaly.