Stratifying the case group of children (C-MICRO) by the severity of microcephaly at birth, in children with severe microcephaly (CSM) and children with microcephaly (CM), the T allele in SNP rs4073 at CXCL8 gene and the T allele in SNP rs179008 at TRL7 was associated with severe microcephaly (Table 5). The gene discussed is CXCL8; the disease is microcephaly.