Here, using hypothesis-driven candidate genes and their previous report in the ZIKV pathogenesis or their function against viral infections or other infection disease, we tested SNPs in TREM120–22, CXCL1011,23, IL424,25, CXCL826, TLR319, TLR727–29, IFNR130,31, CXCR132, IL1033–35, CCR2 and CCR536 genes to investigate their association to CZS, in a cohort of mothers who had delivered CZS infants, their infants and healthy donors. Here, CCR2 is linked to viral infectious disease.