ITCH and atherosclerosis: For the FS network, among the seven miRNAs that target 25 genes, miR-17-5p is predicted to regulate most of the genes (13), including BCL2, VEGFA, CXCL8, IL6, MMPs, JAK1, ITCH, TLR3, and TGFBR2, which were previously demonstrated to be associated with atherosclerosis.