For the FS network, among the seven miRNAs that target 25 genes, miR-17-5p is predicted to regulate most of the genes (13), including BCL2, VEGFA, CXCL8, IL6, MMPs, JAK1, ITCH, TLR3, and TGFBR2, which were previously demonstrated to be associated with atherosclerosis. The gene discussed is JAK1; the disease is atherosclerosis.