A wide variety of signaling pathways, including PI3K/AKT, NF-κB, P53, and AKT/mTOR/p70S6K, are participated in the regulation of OC cells biological behavior, and non-coding RNAs such as miRNA also play a role, which shows that curcumin’s anti-tumor properties are based on multiple pathways, targets, and systems. Here, RPS6KB1 is linked to neoplasm.