ADORA2A and cancer: Meanwhile, Sidders et al. proposed another genomic signature termed the “Adenosine Signaling Score” consisting of 14 genes (PPARG, CYBB, COL3A1, FOXP3, LAG3, APP, CD81, GPI, PTGS2, CASP1, FOS, MAPK1, MAPK3, CREB1), which exhibited good correlation with A2AR signaling in human cancers and could be used to predict immunotherapeutic response [134].