In a clinical trial, an anti-CD73 mAb (MEDI9447) with or without durvalumab (PD-L1 mAb) was reported to downregulate CD73 expression on peripheral T cells in 66 pancreatic and colorectal cancer patients, which was associated with an increase in cytotoxic T-cell infiltration [101]. Here, NT5E is linked to colorectal cancer.