TP53 and cancer: Mutant p53 activates the Warburg effect by promoting the translocation of the GLUT1 to the plasma membrane, thereby enhancing tumor metabolism.101 Mutant 53 binds and activates PGC-1α, a major regulator of oxidative phosphorylation, enhancing mitochondrial function and promoting cancer metastasis.102,103 These studies suggest that mutant p53 may confer metabolic plasticity to cancer cells, thereby promote their adaptation to metabolic stress and increase their potential for proliferation and metastasis.