TP53 was mutated more frequently in esophageal carcinoma (93.77%), small cell lung cancer (79.06%), ovarian carcinoma (80.46%), colorectal carcinoma (74.45%) and gallbladder carcinoma (57.77%), and less frequently in thyroid carcinoma (3.13%), embryonal tumor (2.08%) and peripheral nervous system (1.25%). The gene discussed is TP53; the disease is small cell lung carcinoma.