The tumor suppressor gene TP53 is the most frequently mutated gene in human tumors.1,2 The process of tumor development is strongly related to the dysfunctions caused by TP53 mutations.3,4 p53 protein functions primarily as a transcription factor, which regulates a wide variety of pathways, such as cell cycle arrest, DNA repair, cell apoptosis, autophagy, and metabolism,1,5,6 and determines whether cells die under stress conditions. This evidence concerns the gene TP53 and neoplasm.