TP53 and cancer: The MDM2 inhibitor RG7388, which was subsequently designed and synthesized, is a class of pyrrolidine derivatives.344 RG7388, Kd = 0.15 nM, induces dose-dependent apoptosis in wild-type p53 cancer cells.342 Structurally, the 4-chlorophenyl ring, 3-chlorophenyl group and neopentyl group mimic p53 occupying the Phe19, Trp23 and Leu26 pockets.