The development of hepatocellular carcinoma and other related phenotypes no longer occurred after knockdown of TP53, suggesting that p53-accumulated mice do promote the development of hepatocellular carcinoma.196 Cellular activities regulated by p53 are integrated into tumor suppressive functions, but p53-induced regulation of certain elements may also provide a survival advantage for tumors (Fig. 3). The gene discussed is TP53; the disease is hepatocellular carcinoma.