C14586 is the first orally bioavailable mutant p53 protein-selective reactivator that selectively binds to the cleft produced by the p53 Y220C mutant protein, thereby restoring wild-type p53 protein structure and tumor suppressor function.479 Preclinical trials have shown that continuous oral administration leads to complete tumor regression in 80% of mice.479 An ongoing clinical phase 1/2 study will evaluate the safety, tolerability and antitumor activity of C14586 in adult patients with advanced or metastatic solid tumors with the Y220C mutation.480. This evidence concerns the gene TP53 and neoplasm.