TP53 and neoplasm: Salim et al. identified a thiosemicarbazideb compound COTI-2 that showed inhibitory activity in a variety of tumors by using a computational platform.448 COTI-2 inhibits tumor growth in a p53-dependent and p53-independent manner, ultimately leading to cell cycle arrest and apoptosis.448–450 COTI-2 was reported to restore DNA-binding properties to the p53-mutant protein,449,451–453 whereas it is obscure whether COTI-2 can physically bind p53.