TP53 and neoplasm: However, in many situations, missense mutant p53 is expressed at high levels in tumor cells, partly due to the inability of mutant p53 to induce gene expression of MDM2,379 which supports the reactivation of mutant p53 as a therapeutic option.5 Most TP53 mutations are missense mutations located in the DBD.3,4,203,205,380 p53 mutants mainly affect the thermostability of p53 protein, structural stability (structural mutants such as 175, 220, 245 and 249) or p53-DNA contact (DNA contact mutants such as 248 and 273).