Mutant p53 binds directly to TBK1, prevents TBK1 from forming a ternary complex with STING and IRF3, and ultimately inhibits the activation of the cGAS-STING pathway.223 Mutant p53 helps tumor tissue evade the killing effect of the immune system by inhibiting the anti-tumor immune response.223,247,248 However, in contrast, the evidence on the effects of p53 mutant GOF is much weaker compared to DN, and it may act modestly or only in certain specific situations. Here, IRF3 is linked to neoplasm.