TP53 and neoplasm: CP-31398 inhibited ubiquitination and degradation of p53457 and activated BAX independently of p53 to promote apoptosis of tumor cells.455 Molecular docking structures revealed that STIMA-1,458 MIRA-1459–461 stictic acid424 and UCI-LC0023462 could bind in the L1/S3 pocket of p53-DBD, probably to the thiol group of Cys124 in this transiently opened pocket.424