However, it induces the expression of epithelial-mesenchymal transition markers and enhances the viability and invasiveness of cancer cells.565 Overexpression of Δ133p53α facilitates the long-term propagation of primary epithelial cells in vitro.569 These evidences suggest that some p53 isoforms are in marked contradiction to the function of wild-type full-length p53, exhibit oncogenic effects, and support cancer cell proliferation and invasion. The gene discussed is TP53; the disease is cancer.