TP53 and cancer: In p53-silenced cells, the response of ReACp53 was not abolished, and addition of this peptide to p53-silenced two-dimensional cultured cancer cells resulted in rapid apoptosis.495 Thus, although ReACp53 was designed as a mutant p53 rescue compound, its exact mechanism of action and targeting in tumors and whether it acts primarily by targeting p53 need to be further elucidated.