For diffuse large B-cell lymphoma (DLBCL) patients, Nie M et al. investigated the mechanism of interleukin-8 (IL-8), secreted by lymphoma cells, binding to C-X-C Motif Chemokine Receptor 2 (CXCR2) on the cell-surface of neutrophil and inducing NET formation. Here, CXCL8 is linked to diffuse large B-cell lymphoma.