Immature MDSCs with potent immunosuppressive activity accumulate during cancerous development.16 In mouse tumor model, two main MDSC subtypes have been characterized: monocytic myeloid-derived suppressor cells (M-MDSCs) labelled as CD11b+Ly6G−Ly6Chigh, and granulocytic polymorphonuclear MDSCs (PMN-MDSCs) labelled as CD11b+Ly6G+Ly6Clow. This evidence concerns the gene ITGAM and neoplasm.