DTX is one of the most widely used antimitotic chemotherapy drugs for the treatment of cancers.56 It has been reported that DTX possesses chemo-immunomodulatory properties besides its canonical antitumor properties.57,58 Our recent reports showed that DTX induced C-C motif chemokine ligand 3 (CCL3) secretion in macrophages and triggered proinflammatory polarization of macrophages to inhibit breast cancer progression.59 However, most patients eventually become chemo-resistant accompanied with tumor progression. This evidence concerns the gene CCL3 and neoplasm.