We screened top ten upregulated genes in chemokine signaling pathways and the top fifty up-regulated genes in all sequenced genes, and consistently found CXCL2 and its receptor CXCR2 were significantly upregulated in CCL20-modulated PMN-MDSCs and tumor cells, respectively (Fig. 4c, d and Supplementary Fig. S12a, b). The gene discussed is CXCL2; the disease is neoplasm.