Of note, mesenchymal genes Mmp2, and vimentin (Vim) (Fig. 5D, yellow points) were upregulated in cluster 6, while epithelial genes E-cadherin (Cdh1) and Epcam (Fig. 5D, orange points) were downregulated, suggesting that the emergence of basal-like characteristics in these luminal-derived tumor cells may result from an epithelial to mesenchymal transition (EMT). The gene discussed is MMP2; the disease is neoplasm.