Specifically, the Brca1F22–24/F22–24;p53+/− mouse tumor model [58] more accurately reflects mammary epithelial transformation in human patients by introducing Brca1 mutation and loss of p53. When crossed with BLG-Cre mice to induce oncogenesis in milk-producing luminal cells, this mouse model was shown to produce tumors that are basal-like and metaplastic. This evidence concerns the gene TP53 and neoplasm.