Depletion of either Dnah2 or WD repeat domain 78 (Wdr78), another dynein f subunit, by RNAi in mouse ependymal cells resulted in increased incidence of paralyzed motile cilia, and interestingly, knockdown wdr78 zebrafish larvae displayed hydrocephalus [61]. The gene discussed is DNAI4; the disease is Hydrocephalus.