ALKBH5-mediated removal of m6A deposition from the lncRNA NEAT1 enhanced transcript stability and NEAT1-mediated paraspeckle assembly, which resulted in the relocation of the transcriptional repressor SFPQ from the CXCL8 promoter to paraspeckles, increasing CXCL8/IL8 expression and contributing to TAM enrichment and tumour progression. This evidence concerns the gene CXCL8 and neoplasm.