CD274 and intrahepatic cholangiocarcinoma: In intrahepatic cholangiocarcinoma (ICC), ALKBH5 interacts with tumour PD-L1 to remove m6A deposition in the 3’UTR of PD-L1 mRNA, therefore preventing YTHDF2-mediated RNA decay and sustaining PD-L1 expression, which represses the proliferation of cytotoxic T cells [132].