Interestingly, in a lactate-enriched TIME, lactylation drove METTL3 upregulation in tumour-infiltrating myeloid (TIM) cells and enhanced the immunosuppressive function of TIM cells through YTHDF1-mediated Jak1 translation and the subsequent phosphorylation of STAT3 [126]. The gene discussed is METTL3; the disease is neoplasm.