Hemophilia is a kind of hereditary hemorrhagic disease with X-linked recessive inheritance caused by coagulation factor deficiency, including hemophilia A and hemophilia B. Hemophilia A with a functional defect of factor VIII (FVIII) caused by mutations of the F8 gene in locus Xq28 accounts for 80%-85% of hemophilia cases [1]. Here, F8 is linked to hemophilia.