Moreover, tumor-derived granulocyte macrophage colony stimulating factor (GM-CSF) activates neutrophils and induces neutrophil B7-H3 expression via JAK-STAT3 signaling pathway [72], while miR‐34a induces immunosuppression through modulating a SIRT1/NF‐κB/B7‐H3/TNF‐α axis [73]. This evidence concerns the gene STAT3 and neoplasm.