Significant risk factors for AKI development at univariate analysis were the following: comorbidities variables – age, diabetes, hypertension, ACEi or ARB use, chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD); ICU admission variables: need for mechanical ventilation or vasopressors, serum potassium > 4.2 mEq/L, serum sodium < 140 mEq/L, pH < 7.35, pCo2 > 48 mmHg, c-reactive protein (CRP) > 8.7 mg/dL and lymphocytes < 720 (Table 2). The gene discussed is CRP; the disease is chronic kidney disease.