SIGLEC1 and neoplasm: In view of corresponding phenotype and function, Macrophages can be divided into classically activated Macrophages (M1) and alternatively activated Macrophages (M2).While M1 macrophages stimulate tumor antigen presentation, M2 macrophages inhibit tumor-antagonizing immunocyte‐killing activity via interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and transforming growth factor‐β (TGF‐β) production [12, 13].In addition, there are three additional subtypes of Macrophages, including tumor-associated Macrophages (TAM), CD169 + Macrophages and TCR + Macrophages.