In addition, TAM and M2 Macrophages can promote chronic inflammation, angiogenesis, and tumor growth by secreting various cytokines, growth factors (e.g., EGF, VEGF, PDGF, FGF and TGFβ), matrix metalloproteinases (MMPs), M-CSF, etc. [20–24]. This evidence concerns the gene EGF and neoplasm.