Furthermore, recent studies have evidenced that NLRP3 inflammasome promote pyroptosis by inducing the cleavage of gasdermin-D, whereas autophagic degradation of gasdermin-D could retard IDD by inhibiting NPC pyroptosis (Wang et al. 2020; Liao et al. 2021). Here, NLRP3 is linked to intervertebral disk degenerative disorder.