CFL1 and leukemia: On the other hand, analysis of how 5 induceddifferentiation found four up-regulated proteins, including galactin-10,plectin 1, AUF1, and electron transfer flavoprotein α-subunit,and 14 down-regulated proteins, including DJ-1, cofilin 1, RhoGDPdissociation inhibitor 2 (RhoGDI2), calreticulin (CTR), and proliferatingcell nuclear antigen (PCNA).54 All of theabove suggest that the effects of 5 on leukemia cellsmay be due to the modulation of multiple targets.