38 Regarding breast cancer, 4 has been shown to effectively inhibit tumor cell proliferation,control cell cycle transitions, decrease lipid peroxidation, and attenuateDNA strand breaks.39,41 Combination therapy with 4 and paclitaxel (18) in rats with induced skincancer not only effectively reduced Bcl-2 protein expression and increasedp53 gene expression but also restored skin architecture.42 The gene discussed is BCL2; the disease is neoplasm.