Therefore, drugsthat can decrease HIF activity could reduce primary tumor growth,vascularization, invasion, and metastasis in breast cancer.78,79 DAT (6) seems to be a potential HIF-1α inhibitor,since it can attenuate the metastatic potential of breast cancer MDA-MB-231cells in hypoxia-induced embryonic zebrafish, xenograft, and orthotopictumors and can efficiently inhibit HIF-1α expression.80 On the other hand, another report showed that 6 inhibited the expression of the α-secretases ADAM10and ADAM17 in estrogen-independent MDA-MB-231 and estrogen-dependentMCF-7 breast cancer cells. Here, ADAM17 is linked to breast carcinoma.