NFE2L2 and neoplasm: It seems to promotecarcinogenesis and tumor progression.84,85 DAT (6) can inhibit Srx expression and ROS levels in gastric cancerBGC823 cells.86 Likewise, 6 inhibits the proliferation of human gastric carcinoma AGS cellsby promoting apoptosis and accumulation of cells in the G2/M phasethrough ROS-dependent activation of the AMPK pathway.87 In another study performed in BGC-823 cells, 6 also induced cell cycle arrest at the G2/M phase, with significantoverexpression of cyclin A2 and B1, and apoptosis through the attenuationof Nrf2/Akt and activation of p38/JNK.