The Trx system is an efficient antioxidantsystem that protects cancer cells from oxidative damage.68,69 Garlic-derived 6 has been reported to inhibit Trx reductaseand the expression of Trx-1 in breast cancer cells.70 Specifically, 6 reduced Trx-1 nuclear translocationfrom the cytoplasm, with the consequent reduction of Trx-1 formation. Here, TXN is linked to cancer.