A study was performed in which 5 inhibitedcell migration and invasion by suppressing the phosphorylation ofactin-depolymerization factor (ADF)/cofilin in colon SW480 cells.The inhibition of phosphorylation by 5 was effected viadown-regulation of LIMK1, a result that may suggest LIMK1 as a potentialtarget molecule in this type of cancer.59 This evidence concerns the gene TXN and cancer.