CFL1 and leukemia: Cofilin 1 has been shown to be highly expressed in several cancertypes and is associated with proliferation, migration, invasion, differentiation,metastasis, and poor prognosis.50,51 Therefore, cofilin1 silencing by 5 leads to inhibition of proliferationand induced differentiation of leukemia HL-60 cells.52 In addition, 5 has been shown to inhibit thegrowth of tumor tissue in immunodeficient mice injected with HL-60cells.53 As well as being able to inhibitthe proliferation of, migration of, and invasion by leukemia cancercells, 5 can arrest cells at the G0/G1 stage at low doses(8 μM).