The other water-soluble allyl amino acid derivative, SAMC(9, Figure 2), has shown anticancer activity through down-regulating Bcl-2 protein,which causes tumor cell apoptosis by a process involving activationof the mitogen-activated protein kinase (MAPK) pathway and mitochondrialcytochrome c release.24 Moreover, 9 can inhibit tumor cell proliferation byinducing histone acetylation and inhibiting microtubule polymerization.It induces E-cadherin to suppress tumor cell migration. Here, WNK2 is linked to neoplasm.