In detail, IBD had high support for colocalization with 9 proteins including CARD9 (caspase recruitment domain-containing protein 9), CXCL9, ERAP2 (endoplasmic reticulum aminopeptidase 2), HGFAC, IL12B (interleukin-12 subunit beta), MST1 (hepatocyte growth factor-like protein), STAT3, TIMD4 (t-cell immunoglobulin and mucin domain-containing protein 4), and TNFRSF9 (tumour necrosis factor receptor superfamily member 9); of these, CARD9, IL12B, MST1, and TNFRSF9 were validated in the replication dataset (Fig. 3 and Supplementary Table S7). This evidence concerns the gene CARD9 and irritable bowel syndrome.