For 1-SD increment of genetically predicted levels of protein, the odds ratio (ORs) of IBD was 0.86 (95% CI 0.84–0.89) for MST1, 0.54 (95% CI 0.40–0.73) for NADK, and 0.92 (95% CI 0.89, 0.96) for HGFAC. Here, MST1 is linked to irritable bowel syndrome.