Herein, we evaluated if the expression of E-cadherin, STAT3, NF-κB, CD163, PD-L1, and CXC12 would be associated with a poor prognosis for patients with tumours with low (1/2) and high (3/4) modified Dukes’ classification in primary CRC. This evidence concerns the gene NFKB1 and colorectal carcinoma.