Treatment of MDS-RS cells with vitamin B5 significantly increased maturation of CD71+CD235a+ and CD71-CD235a+ (p<0.05), whereas treatment with succinyl-CoA rescued erythroblasts maturation and heme production in patients with MDS-RS (Fig 6C-D & Fig. S6A-E). This evidence concerns the gene TFRC and myelodysplastic syndrome.