GPT and cancer: Among the various molecular systems, pyruvate plays a crucialrolein deregulated glycolytic pathways in diseases associated with inflammation,neurodegeneration, and cancer.41,42 As the end productof glycolysis, pyruvate might be converted into alanine via alanine transaminase (ALT) or lactate via lactatedehydrogenase (LDH), or it can enter the tricarboxylic acid cycle(TCA) via the catalysis of the pyruvate dehydrogenasecomplex (PDH).