Among females with a PV in a BC risk gene (ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NBN- 657del, NF1, PALB2, PTEN, RAD51C, RAD51D, and TP53), 22.5% (86/383) had a subsequent BC diagnosis. The gene discussed is NBN; the disease is breast cancer.