For the combination of BC and sarcoma (n = 150), PVs were most frequent in TP53 (3.3%, 95% CI 1.2–8.0%) followed distantly by BRIP1 and CHEK2. Among 80 females with BC and brain cancers, 11 had PVs of which PVs in BRCA2 (n = 4, 5.0%, 95% CI 1.6–13.0%) occurred most frequently. The gene discussed is TP53; the disease is brain cancer.