Among the 2,687 patients with a first diagnosis of BC, 16.4% harbored a PV in a BC risk gene (ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NBN- 657del, NF1, PALB2, PTEN, RAD51C, RAD51D, and TP53), 10.5% in an OC risk gene ((BRCA1, BRCA2, BRIP1, PABL2, RAD51C, RAD51D and MMR genes)), and 1.5% in an DNA MMR gene (MLH1, MSH2, MSH6, and PMS2). The gene discussed is MSH2; the disease is breast cancer.