CASP3 and Alzheimer disease: Many previous studies reported that CUR alone has antioxidant and anti-inflammatory activities, decreases Aβ1-42 deposits, p-tau (Ser202) aggregation, decreases caspase-3 hippocampal levels and acts as anti or decreases cholinesterase activity, with concurrent improvement in the cognitive function in different AD animal models induced by many substances including SCO (Lin et al. 2020; Huang et al. 2016; Akinyemi et al. 2017; Banji et al. 2014).