According to the spatial–temporal sequencing of Aβ accumulation, the regions with positive Aβ VR that showed a significant interaction with APOE-ε4 status on cognitive decline (temporal regions and the striatum) are typically considered to be accumulating Aβ later in the AD continuum than those in which this interaction was not found (e.g. frontal and PC/PCC) [7]. The gene discussed is APOE; the disease is Alzheimer disease.