As the PD‐1 signaling pathway and IL‐10 signaling pathway are key pathways for immunosuppression,38, 39 these results suggest that immunosuppression and innate immune dysregulation may play an important role in the progression of diffuse glioma, which further suggests that diffuse glioma is a kind of tumor that highly associated with immune dysfunction. Here, PDCD1 is linked to neoplasm.