CAF_CM also increased GBM neurosphere diameter in a manner reduced by combining anti-HGF and anti-OPN antibodies in GBM6 (P < 0.001; Supplemental Figure 23A) and GBM43 (P < 0.001; Supplemental Figure 23B and Supplemental Figure 24) neurospheres grown in GBMpt5CAF CM. This evidence concerns the gene SPP1 and glioblastoma.