Immunofluorescence of tumor vasculature labeled via rhodamine B-dextran perfusion revealed that CAFs caused GBM6 neurosphere-derived tumors to exhibit increased total vessel area/high-power field (hpf) (n = 3 mice/group; P = 0.02) (Figure 7, E and F) due to CAFs increasing the area of individual vessels (P = 0.0002; Figure 7F) without altering vessels/hpf (P = 0.3; Supplemental Figure 47). The gene discussed is TBX1; the disease is neoplasm.