Third, we identified the most differentially expressed genes between cells with high CAF probability scores versus those without, which included genes expressed by CAFs in other cancers: CCDC80 (24), BGN (25), COL4A2 (25), COL5A1 (25), NR2F2 (17), COL3A1 (25), INHBA (25), STC2 (26), and LOXL2 (25) (Supplemental Figure 10). This evidence concerns the gene COL5A1 and cancer.