Similar results were observed also in the case of EGF‐stimulated secretion of three separate soluble cargo proteins, MMP2, MM9 (Fig EV5D–F), and Collagen (Fig EV5G and H); these cargo proteins were chosen because of GIV's published role in ECM degradation during cancer metastasis (Rahman‐Zaman et al, 2018) and tissue fibrosis (Lopez‐Sanchez et al, 2014). Here, MMP2 is linked to cancer.