In 2012, Rizwanul Haque et al. reported the differentiation of Treg cells from iPSCs by forced expression of Foxp3 and coculture on Notch ligand‐expressing stromal cells, they demonstrated that the iPSC‐derived Treg cells significantly suppressed host immune responses and reduced arthritis development within murine models.58 This evidence concerns the gene FOXP3 and Arthritis.