Furthermore, we provide evidence that miR‐31‐induced secretion of cytokines and aspartate is sufficient to induce Th17 differentiation in vitro and blocking SLC1A3‐mediated aspartate uptake using TFB‐TBOA, and further conversion to oxaloacetate by AOA reduces Th17 differentiation and importantly, also affect psoriasis pathology in the IMQ model similar to CB‐839. This evidence concerns the gene SLC1A3 and psoriasis.