The former relies on the induction of EMT in cancer cells through bidirectional crosstalk of paracrine signals (with specific engagement in deregulated pathways such as IL‐6, IL‐11 and TNF‐α) to activate stemness‐related pathways and metabolic reprogramming of tumour cells, while the latter promotes cancer cells for invasion of ECM by co‐migration or ECM remodeling to favour its metastatic potential.49 This evidence concerns the gene IL6 and cancer.