RGS5 and cancer: Previous reports have also highlighted a subcluster called vCAF in malignant tumours,37, 38 characterised by microvasculature signature genes such as CD146 (MCAM), MYH11 and RGS5, as well as inflammatory chemokines such as IL‐6 and CCL8, with functions mainly in response to hypoxia and mesenchymal cell proliferation.