HES1 and neoplasm: Results showed that the high value of regulatory potential between MFAP5 and some of its top predicted NOTCH1/WNT pathway target genes (CCND1, HES1, MYC, RBPJ, NOTCH1, CCN3, CTNNB1 and SOX17) in inferring signaling paths in tumour tissues (Figure S12C,D).