ZFAS1 and metastatic malignant neoplasm in the lymph nodes: Other studies have shown that the upregulation of ZFAS1 was positively correlated with the clinicopathological features and prognosis of most tumors, such as TNM stage, lymph node metastasis, overall survival and prognosis, and can be used as a biomarker for the prognosis of many kinds of cancer patients (Romano et al., 2017; Lan et al., 2017).