Most infiltrating immune cells were significantly different in patients with NS compared to the control group; activated CD8 + T and B cells, CD56 natural killer cells, naïve dendritic cells, and T helper cells were significantly enriched in the sepsis group, whereas activated dendritic cells, memory CD8 + T cells, macrophages, plasmacytoid dendritic cells, and neutrophils were significantly enriched in the control group. This evidence concerns the gene CD8A and Sepsis.