The defining neuropathological hallmarks of Alzheimer’s disease (AD) are an extracellular accumulation of aggregated amyloid-β fragments, typically associated with degenerating neurites (amyloid-β neuritic plaques), and intracellular aggregates of abnormally phosphorylated microtubule-associated tau protein (neurofibrillary tangles [NFTs]) [1, 2]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.