We have already shown the anti-viral effects of the compounds K-4 and M-4 in SARS-CoV-2 Omicron spike protein-infected lung organoid models (Fig. 7), and the mechanism of action was proven by molecular docking results: compounds bind to the spike and inhibit the interaction between the spike and ACE2 to block virus infection. The gene discussed is ACE2; the disease is viral infectious disease.