Of note, the study includes CHD patients with no relevant variants in known CHD-related genes such as NOTCH1, NOTCH2, GATA5, GATA4, ACTA2, SMAD6, NKX2-5, FLT4, TGFBR1, and TGFBR2. Here, TGFBR1 is linked to coronary artery disorder.