ROCK2 and brain ischemia: For example, miR-21 reduces neuronal apoptosis during cerebral ischemia by targeting the Fas ligand, miR-148a-3p modulates Rock2 expression to alter oxygen–glucose deprivation/reperfusion (OGD/R)-induced oxidative stress [17], and miR-421-3p inhibits activation of the NF-κB pathway and reduces inflammation after cerebral ischemia [18].