Imagine examination before surgery showed: CTS was 4.2*2.5 cm (MG), 3.50*1.05 cm (US), tumor central location, and TND was 1.21 cm (MG), 1.54 cm (US), cN ( −), Preoperative CNB biopsy: invasive ductal carcinoma, G2, ER +  + (85%), PR (+ , 50%), HER-2 ( −), and KI67 (35%). The gene discussed is ESR1; the disease is invasive ductal breast carcinoma.