Although in vitro studies have been conducted to explore the potential function of Caprin-1, the underlying mechanisms of signaling pathways in ESCC has not been fully elucidated, thus further investigation is required to confirm the role of Caprin-1 in ESCA growth and progression in patients, and its relationship with glycolysis and m6A methylation in the tumor microenvironment. This evidence concerns the gene CAPRIN1 and esophageal squamous cell carcinoma.