There was no significant difference between ADAM12 rs1871054 in Europeans and the allele conferring susceptibility to osteoarthritis in all gene models [allelic model (T vs. C), OR = 1.33, 95% CI (0.91–1.95), P = 0.019, I2 = 66.0%], suggesting that Asian patients carrying the C allele are more prone to the disease. Here, ADAM12 is linked to osteoarthritis.