Subgroup analysis showed that there was a significant difference between ADAM12 rs1871054 and osteoarthritis susceptibility in Asian samples of dominant, recessive, allelic, and homozygous models [e.g., allelic model (T vs. C), OR = 1.61, 95% CI (1.25–2.08), P = 0.055, I2 = 65.6%] (Fig. 3A); however, only three studies were included. This evidence concerns the gene ADAM12 and osteoarthritis.