We found no statistically significant differences between ADAM12 Rs1871054 polymorphism and susceptibility to osteoarthritis in the dominant, recessive, allele, and homozygous models [allelic model (T vs. C), OR = 1.34, 95% CI (1.05–1.71), P < 0.001, I2 = 76.4%], as shown in Fig. 2B. However, there was no statistical significance in the heterozygous model [OR = 1.07, 95% CI (0.88–1.30), P = 0.907, I2 = 0%], suggesting patients carrying the TC allele and those with TT had the same risk of disease. Here, ADAM12 is linked to osteoarthritis.