The present study has several noteworthy findings: First, with regard to the relationship between the levels of systemic inflammation indicators and the risk of various arrhythmias, CRP showed a linear positive correlation; monocyte count, neutrophil count, and NLR showed a nonlinear positive correlation; lymphocyte count, SII, PLR, and LMR showed a U-shaped association. The gene discussed is CRP; the disease is Arrhythmia.