According to Meta-analysis results, no correlation was found in preoperative NLR on tumor clinicopathological characteristics, including the number of metastases (OR = 1, 95% CI = 0.76–1.31, P = 0.97), CEA (OR = 1.31, 95% CI = 0.88–1.96, P = 0.19), primary tumor size (OR = 1.22, 95% CI = 0.90–1.67, P = 0.2) and time to metastasis (OR = 1.12, 95% CI = 0.78–1.62, P = 0.54)). Here, CEACAM5 is linked to neoplasm.