It is important to highlight that the unique phenotype of the aging post-stroke BBB recovery is in part dependent on an altered profile of normal aging brain endothelial cells, as genes related to endothelial to mesenchymal transformation Smad6 (p.adjust = 0.00011, q-value = 3.36E−09), and epigenetics, histone demethylase Kdm6a (p.adjust = 6.73E−15, q-value = 3.82E−06) are significantly upregulated at the transcription level in aged versus young non-stroke mice. The gene discussed is SMAD6; the disease is Stroke.