Overall, post-TE stroke changes to the DNA methylome largely affected genes encoding cell structural proteins (e.g., cell junction, and cell polarity, actin cytoskeleton, extracellular matrix, membrane microdomain), transporters and channels (e.g., potassium, organic anion and inorganic cation, calcium ion transport), and proteins involved in endothelial cell processes (e.g., angiogenesis and vasculogenesis, cell signaling and transcription regulation) (Fig. 2d, e). The gene discussed is PROS1; the disease is stroke disorder.