E2F4 and head and neck squamous cell carcinoma: Our results showed the positive regulation of E2F2 and E2F8 but the negative regulation of E2F4 on B cells, CD8+ cells, and NK cells in males and this could be correlated with the suppressive function of E2F4 but improved effects of E2F2 and E2F8 on the OS of male HNSCC patients.