The high expression of IFN-induced genes and enrichment of IFN-related responses observed here suggest that accumulation of type-1 and type-2 IFNs (Fig. 2f, g, Additional file 2: Figure S2c), due to chronic inflammation or viral infections, might have a significant impact on the make-up and functionality of these T cells. The gene discussed is IFNA1; the disease is viral infectious disease.