PRF1 and Sepsis: S1PR5, GNLY, CD247, KLRG1, IL-1R2, AUTS2, IL-2Rβ, ARG1, TGFBR3, TLR5 and PRF1 in the top 80 genes in the two modules were located toward the center of the co-expression network, and CD247, IL-2Rβ, TGF-βR3 and IL-1R2 were identified as core genes in sepsis (Fig. 4C-D).