IL1R2 and Sepsis: Combining the survival and meta-analysis, we speculated that IL-1R2 expression increased in sepsis due to the binding of up-stream lncRNA with hsa-miR-18b-5p, hsa-miR-20a-5p, hsa-miR-454-3p and hsa-miR-548k, which negatively regulated IL-1 level leading to decline of the body’s anti-inflammatory capability and subsequent sepsis development and patient death.