Knowing that a study performed in an urban township of Cape Town observed a very high (88.0%) latent TB infection (LTBI) prevalence rate among PLWH [36] and SARS-CoV-2 infection decreases TB–specific CD4 + T cell response [8], many concerns have been raised about the possibility that COVID-19 could reactivate latent TB in a high TB-endemic setting such as Khayelitsha district. The gene discussed is CD4; the disease is COVID-19.