The results of the present study revealed that during the diagnosis and treatment of patients with purely hepatic WD, the elevated ALT and AST levels and 24-h urinary copper level in the NH-WD group were higher than those in the H-WD group, and the adherence to low-copper diet and the average daily oral doses of PCA and ZG in the NH-WD group were lower than those in the H-WD group. This evidence concerns the gene GPT and Wilson disease.